Secondary Polycythemia in Hepatocellular Carcinoma: Treat or No Treat

Breast carcinoma: treat or overtreat.

Targeting vessels to treat hepatocellular carcinoma.

The process of blood vessel proliferation, known as angiogenesis, is essential during embryonic development and organogenesis. In adult life, it participates in normal tissue repair, wound healing, and cyclical growth of the corpus luteum and the endometrium. Crucial as it is, angiogenesis can become pathological, and abnormal angiogenesis contributes to the pathogenesis of inflammatory and neo...

How I treat How I treat polycythemia vera

Polycythemia vera (PV) is a clonal disorder characterized by unwarranted production of red blood cells. In the majority of cases, PV is driven by oncogenic mutations that constitutively activate the JAKSTAT signal transduction pathway, such as JAK2 V617F, or exon 12 mutations or LNK mutations. Diagnosis of PV is based on the WHO criteria. Diagnosis of post-PV myelofibrosis is established accord...

How I Treat How I treat polycythemia vera

I will take advantage of the history of two gentlemen that I encountered in the office some years apart to illustrate how I manage subjects referred for the investigation of erythrocytosis and are then found to have polycythemia vera (PV) rather than relative or secondary erythrocytosis (Table 1). Therefore, this manuscript is not intended to provide a thorough description of the disease or to ...

An oncolytic parasite to treat polycythemia vera

An oncolytic parasite to treat polycythemia vera I n recent years, there has been a surge of clinical trials to treat various kinds of cancers with non-replicating versions of viruses (1). The most famous among these is the recent use of a genetically engineered poliovirus used to treat one of the most difficult-to-treat and recurring cancers Á Glioblastoma Multiforme (2, 3). In addition, vario...